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Singh, Arvind Kumar
- 1, 2, 4- Triazole Derivatives and its Pharmacological Activities
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Affiliations
1 Kamla Nehru Institute of Management and Technology (Faculty of Pharmacy), Sultanpur UP-228001, IN
1 Kamla Nehru Institute of Management and Technology (Faculty of Pharmacy), Sultanpur UP-228001, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 5 (2013), Pagination: 429-437Abstract
Triazole, a heterocyclic nucleus has attracted a wide attention of the medicinal chemist in search for the new therapeutic molecules. This review provides a brief summary of 1,2,4-triazole Derivatives and its Pharmacological activities and highlights some examples of 1,2,4-triazole-containing drug substances. Either as single heterocyclic derivatives or in fusion with the other cycles, these heterocycle is emerging as the most explored centre to obtain clinically significant compounds. The major activities exhibited by 1,2,4 derivatives include antibacterial, antifungal, antiviral, antidepressant, antimalarial, hypnotic, anticonvulsant and anti-inflammatory activities.Keywords
1,2,4- Triazoles, Pharmacological Activities
References
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- Mevlut Serdar Nurhan Gumrukcuoglu ,Sengul alpay Karaogluaraoglu, Neslihan Demirbas, “Synthesis of Some Novel 3,5-Diaryl-1,2,4-TriazoleDerivatives and Investigation of Their Antimicrobial Activities”, Turk J Chem,2007, 31, 315 – 326 .
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- Syed Azhar Nizami, M. Gurumurthy, Swarup Jyoti Chattarjee, Debashisha Panda, “Evaluation of Antimicrobial Potency of Some Synthesized Thiazolidin-4-one substituted 1,2,4-triazoles”, Journal of Advanced Pharmaceutical Research. 2010, 1, 26-35.
- Monazza Serwar, Tashfeen Akhtar, Shahid Hameed, and Khalid M. Khan, “Synthesis, urease inhibition and antimicrobial activities of some chiral 5-aryl-4-(1-phenylpropyl)-2H-1,2,4- triazole-3(4H)-thiones”, ARKIVOC 2009, (vii), 210-221.
- Nitin Muthal, Jyoti Ahirwar, Dheeraj Ahriwar, Pankaj Masih, Tanaji Mahmdapure and T. Sivakumarm, “Synthesis, Antimicrobial and Anti-inflammatory Activity of Some 5- Substituted-3-pyridine-1, 2, 4-Triazoles”, International Journal of PharmTech Research,2010, Vol.2, No.4, 2450-2455.
- Deniz Sahin, Hacer Bayrak, Ahmet Demirbas, Nelihan Demirbas, Sengul Alpaj Karagolu,“Design and synthesis of new 1,2,4-triazole derivatives containing morpholine moiety as antimicrobial agents,”, Turk J Chem ,2012, 36 , 411 – 426..
- Shantaram Khanage, Popat Mohite, Ramdas Pandhare, Appala Raju, “Synthesis and pharmacological evaluation of isoxazole derivatives containing 1,2,4-triazole Moiety”, Marmara Pharm, 2012, J 16: 134-140.
- Katica Colanceska-Ragenovic, Vesna Dimova, Vlado Kakurinov, Dora Gabor Molnar and Aleksandra Buzarovska, “Synthesis, Antibacterial and Antifungal Activity of 4-Substituted-5-Aryl- 1,2,4-Triazoles”, Molecules 2001, 6, 815- 824.
- Freddy H. Havaldar and Abhay R. Patil, “Abhay R. Patil ,“Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity”, E-Journal of Chemistry, Vol. 5, No.2, pp.347-354, April 2008,Vol. 5, No.2, 347-354 .
- Rambabu Nunna, Ramachandran. D and Viral B. Modi, Kirti J. Goswami et al, “Synthesis, characterization and biological evaluation of 2,6 diphenyl-3-(4-(3-phenyl-[1,2,4]triazolo [3,4b][1,3,4]thione”, Der Pharma Chemica,2012,4 (2),639-643.
- Navin B. Patel and Imran H. Khan, “Synthesis of 1,2,4-triazole derivatives containing benzothiazoles as pharmacologically active molecule” Journal of Enzyme Inhibition and Medicinal Chemistry, 2011; 26(4),527–534.
- E.V.S. Subrahmanyam, B.C. Revanasiddappa, K. Ishwar Bhat, Jisha Prems, P.S.Surya, “Synthesis and biological evaluation of some new 1,2,4-triazolo-[3,4,-b]-1,3,4-thiadiazoles”, J. Chem. Pharm. Res., 2010, 2(5):323-326.
- Raafat M. Shaker, The chemistry of mercapto- and thionesubstituted 1,2,4-triazoles and their utility in heterocyclic synthesis,” ARKIVOC, 2006 ,(ix), 59-112.
- Nubia Boechat ,Luiz C.S. Pinheiro, Osvaldo A. Santos-Filho and Isabor C. Silva, “Design and Synthesis of New N-(5- Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes” Molecules 2011, 16, 8083- 8097 .
- Shantaram G. Khanagea, b, Popat B. Mohite, Ramdas B. Pandhareb, S. Appala Raju,“Study of analgesic activity of novel 1,2, 4-triazole derivatives bearing pyrazole and tetrazole moiety”, Journal of Pharmacy Research 2011, 4(10), 3609-3611.
- Sudeep K. Mandal, Dibyajyoti Saha, Vibhor K. Jain, Bindu Jain,“Synthesis and Antitubercular activity of some triazole derivatives of Propyl Gallate,” International Journal of Pharma Sciences and Research (IJPSR),2010, Vol.1 (11), 465-472.
- Pradeep K Goyal, Anil Bhandari, AC Rana , CB Jain ,“Synthesis of Some 3- Substituted -4H-1, 2, 4-Triazole Derivatives With Potent Anti-Inflammatory Activity”, Asian Journal of Pharmaceutical and Clinical Research 2010, 3, Issue 3, 244-246.
- Abdel-Rahman Farghalya, Abdel-Rahman Farghaly, Erik De Clercq, and Hussein El- Kashef, “Synthesis and antiviral activity of novel[1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles, [1,2,4 ]triazolo[3,4-b][1,3,4] thiadiazines and [1,2,4]triazolo[3,4- b][1,3,4] thiadiazepines”, ARKIVOC 2006, (x), 137-151.
- Asif Husain, Mohammad A. Naseer and Mohammad Sarafroz, “Synthesis and Anticonvulsant Activity of Some Novel Fused Heterocyclic1,2,4-Triazoo-[3,4-b]-1,3,4-Thiadiazole Derivatives”, Acta Poloniae Pharmaceutical n Drug Research, 2009, 66 No. 2, 135-140 .
- Sudhir N. Sambrekar, Suhas A. Patil, “Synthesis of 3- Substituted-4-Amino-5-Mercapto-4(H)-1, 2, 4-Triazole And Screening for Anti-Convulsant Activity”, Apr–Jun 2011, 2 (2) 520-524.
- Mahendra R. Shiradkar, Mangesh Ghodake, Kailash G. Bothara, Shashikant V. Bhandari, Ana Nikalje, C Kalyan Chakravarthy Akula, Nisheeth C. Desai, and Prashant J. Burange, “Synthesis and anticonvulsant activity of clubbed thiazolidinone–barbituric acid and thiazolidinone–triazole derivatives”, ARKIVOC 2007 (xiv), 58-74. .
- Olcay Bekircan, Bahittin Kahveci, Murat Kucuk,“Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl- 4H-1,2,4-Triazole Derivatives”, Turk J Chem, 2006 ,30 ,29 – 40.
- Dhanya Sunil, Arun M Isloor and Prakash Shetty, “Synthesis, characterization and anticancer activity of 1,2,4-Triazolo[3,4-b]- 1,3,4-thiadiazoles on Hep G2 cell lines”, Der Pharma Chemica, 2009, 1(2): 19-26 .
- Dooseop Kim , Liping Wang , Maria Beconi , George J. Eiermann , Michael H. Fisher , Huaibing He , Gerard J. Hickey , Jennifer E. Kowalchick , Barbara Leiting , Kathryn Lyons , Frank Marsilio , Margaret E. McCann , Reshma A. Patel , Aleksandr Petrov , Giovanna Scapin , Sangita B. Patel , Ranabir Sinha Roy , Joseph K. Wu , Matthew J. Wyvratt , Bei B. Zhang , Lan Zhu , Nancy A. Thornberry ,and Ann E. Weber,“(2R)-4-Oxo-4- [3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl) butan-2-amine:i A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes” J. Med. Chem., 2005, 48 (1), 41–151.
- A. Cansiz, M. Koparir and A. Demirdag, “Synthesis of Some New 4, 5-Substituted-4H-1,2,4-triazole-3-thiol Derivatives,” Molecules 2004, 9, 204-212.
- Pharmacological Activities of Benzimidazole Derivatives - An Overview
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Authors
Affiliations
1 Kamla Nehru Institute of Management & Technology (Faculty of Pharmacy, Department of Pharmaceutical Chemistry), Faridipur, Sultanpur, Uttar Pradesh, IN
1 Kamla Nehru Institute of Management & Technology (Faculty of Pharmacy, Department of Pharmaceutical Chemistry), Faridipur, Sultanpur, Uttar Pradesh, IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 5 (2013), Pagination: 448-458Abstract
Benzimidazole derivates play vital role in biological field such as antimicrobial, antiviral, antidiabetic, and anticancer activity. Therapeutic Significance of these clinically useful drugs in treatment of microbial infections encouraged the development of some more potent and significant compounds. Benzimidazoles are remarkably effective compounds both with respect to their bacteria inhibitory activity and their favorable selectivity ratio. Extensive biochemical and pharmacological studies have confirmed that these molecules are effective against various strains of microorganisms. This comprehensive overview summarizes the chemistry of different derivatives of substituted benzimidazole along with their antimicrobial activity.Keywords
Substituted Benzimidazoles, Therapeutic Significance, Antimicrobial ActivityReferences
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- A Review on Text-Independent Speaker Verification Techniques in Realistic World
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Authors
Affiliations
1 Department of Electrical Engineering, North Eastern Regional Institute of Science and Technology, Itanagar, Arunachal Pradesh 791109, IN
2 Department of Computer Engineering, Rajiv Gandhi University, Rono Hills, Doimukh, Arunachal Pradesh, 791112, IN
1 Department of Electrical Engineering, North Eastern Regional Institute of Science and Technology, Itanagar, Arunachal Pradesh 791109, IN
2 Department of Computer Engineering, Rajiv Gandhi University, Rono Hills, Doimukh, Arunachal Pradesh, 791112, IN
Source
Oriental Journal of Computer Science and Technology, Vol 9, No 1 (2016), Pagination: 36-40Abstract
This paper presents a review of various speaker verification approaches in realistic world, and explore a combinational approach between Gaussian Mixture Model (GMM) and Support Vector Machine (SVM) as well as Gaussian Mixture Model (GMM) and Universal Background Model (UBM).Keywords
Speaker Verification, Gaussian Mixture Model, Support Vector Machine, Universal Background Model, Likelihood-Ratio.Full Text
- Allelopathy:How Plants Suppress other Plants
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Authors
Affiliations
1 Bihar Agricultural University, Sabour, Bhagalpur (Bihar), IN
2 Rajendra Central Agriculture University, Samastipur (Bihar), IN
1 Bihar Agricultural University, Sabour, Bhagalpur (Bihar), IN
2 Rajendra Central Agriculture University, Samastipur (Bihar), IN
Source
Rashtriya Krishi (English), Vol 12, No 1 (2017), Pagination: 103-106Abstract
The term allelopathy is from the Greek-derived compounds allelo and pathy (meaning "mutual harm" or "suffering") and was first used in 1937 by Austrian scientist Hans Molisch in the book Der Einfluss einer Pflanze auf die andere - Allelopathie (The Effect of Plants on Each Other) published in German (Willis, 2010).References
- Chang-Hung, Chou (2006). “Introduction to allelopathy”, 2006, Part 1, 1-9.
- Fraenkel, Gottfried S. (1959). “The raison d’Etre of secondary plant substances”, Science, 129 (3361).
- Rice, Elroy Leon (1984). Allelopathy, (1st Ed., November 1974 by the same editor) (IInd Ed.), Academic Press, pp. 422 p. ISBN 978-0-12-587058-0
- Roger, Manuel Joaquín Reigosa, Reigosa, Manuel J.,Pedrol, Nuria and González, Luís (2006). Allelopathy: a physiological process with ecological implications, Springer, p. 1, ISBN 14020-4279-5
- Sheeja B.D. (1993). Allelopathic effects of Eupatorium odoratum L. and Lantana camara,L. on four major crops. M. Phil dissertation, Manonmaniam Sundaranar University, Tirunelveli.
- Stamp, Nancy (2003). “Out of the quagmire of plant defense hypotheses”, The Quarterly Review of Biology 78 (1): 23–55.
- Willis, Rick J. (2007). “The History of Allelopathy”, Springer: 3, ISBN 1-4020-4092-X, retrieved 2009-08-12.
- Willis, R. J. (2010). The History of Allelopathy. Dordrecht, The Netherlands: Springer.
- Importance of Endangered/Rare, Astavarga Medicinal Plants in Traditional System of Medicine in Ayurveda
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Authors
Affiliations
1 Department of Botany, T. D. P. G. College, V.B.S. Purvanchal University, Jaunpur (U. P.), IN
2 CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow (U.P.), IN
3 University of Horticultural Sciences, Bagalkot (Karnataka), IN
1 Department of Botany, T. D. P. G. College, V.B.S. Purvanchal University, Jaunpur (U. P.), IN
2 CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow (U.P.), IN
3 University of Horticultural Sciences, Bagalkot (Karnataka), IN
Source
International Journal of Agricultural Sciences, Vol 14, No 1 (2018), Pagination: 258-265Abstract
Astavarga means group of eight rare and threatened species of medicinal value plants in traditional system of Ayurvedic medicine. The important members of Astavarga group are Kakoli, Kshirkakoli, Jeevak, Meda, Mahameda, Rishbhak, Ridhhi and Vridhii which commonly occur in Himalayan region. But most of the Astavarga plant members have been included among 560 plants appearing in the red list of threatened and endangered species. Plants of Astavarga group make important ingredient of various classical Ayurvedic formulations like Chyavanprasha and many herbal drugs. According to ancient Materia Medica dealing with Ayurveda, Astavarga has been assigned various medicinal properties such as Jeevaniya (drugs strengthening vitality, immunity system etc.), Brhnayiya (increase flesh in the body by activating cell regeneration even in old age) and Vayasthapan (metabolic processes especially anabolism become active and leads to youthful body complexion). Taking in to consideration of their medicinal properties, there is an urgent need to protect, cultivate and popularize the demand of these medicinal value plants among common people. This review article discuss with the properties and medicinal importance of these rare and endangered Astavarga plant species in Ayurveda, traditional system of medicine as well as about their suitable alternative substitute.Keywords
Astavarga, Ayurveda, Endangered, Medicinal Plants.References
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- Estimation of Effective Debye Temperature of Multi Component Liquid Mixtures at 298.15k
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Authors
Affiliations
1 Department of Physics, V.S.S.D. College, Kanpur-208002, IN
2 College of Engineering Science & Technology, Lucknow-226010, IN
3 Department of Chemistry, BITS Pilani, K.K. Birla Goa Campus, Zuarinagar, Goa-403726, IN
4 Amity Institute of Applied Sciences, Amity University, Noida-201313, IN
1 Department of Physics, V.S.S.D. College, Kanpur-208002, IN
2 College of Engineering Science & Technology, Lucknow-226010, IN
3 Department of Chemistry, BITS Pilani, K.K. Birla Goa Campus, Zuarinagar, Goa-403726, IN
4 Amity Institute of Applied Sciences, Amity University, Noida-201313, IN
Source
Journal of Pure and Applied Ultrasonics, Vol 41, No 1 (2019), Pagination: 19-23Abstract
The Debye temperature has been computed for four quaternary mixtures over the entire range of composition at 298.15K. We have applied three different approaches and evaluated the Debye temperature using experimental data of ultrasonic velocity and density. This paper aims to portray the comparison of all the three approaches applied on the four quaternary mixtures which is being done for the first time to the best of authors knowledge .A good agreement is observed among the values computed with all the three approaches.Keywords
Debye Temperature, Quaternary Liquid Mixtures, Ultrasonic Velocities, Density.Full Text
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